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The Phase II denomination comes from Williams classic nomenclature and can be misleading, as it reflects the notion of sequential metabolism, where the parent drug is converted to a primary (or first-generation) metabolite, which in turn is subjected

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This gene therapy improved ERG b-wave amplitude, decreased reactive gliosis in the retina, attenuated inner retinal thinning, and reduced RGC loss (298)

doi: 10.1186/s40035-023-00384-8 95 MourtasS.CanoviM.ZonaC.AuriliaD.NiarakisA.laB.et al